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Cell Biology and Physiopatholology

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Academic year 2022/2023

Teachers
Alberto Puliafito (Lecturer)
Fabrizio Pizzagalli (Lecturer)
Year
1st year, 2nd year, 3rd year
Teaching period
NA
Type
NA
Credits/Recognition
10
Course disciplinary sector (SSD)
BIO/10 - biochemistry
Delivery
NA
Language
English
Attendance
Obligatory
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Sommario del corso

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Program

IMMUNE PATHOLOGY AND ORPHAN DISEASES
25th-26th May 2023
Host: Dario Roccatello
Mandatory course for all students
Registration required

ROCK AND ROLLING: NON-CODING RNAS BEAT ALONG THE AXONS
Online Seminar → Link to WebEx
6th June 2023, h 14.30- 16.00 
Host: Guido Serini
Guest: Marie Laure Baudet. head of the Armenise-Harvard Laboratorty of Axonal Neurobiology, University of Trento

MECHANO BIOLOGY OF TUMOR MICROENVIRONMENT
Online Seminar → Link to WebEx
7th June 2023, h 11.30 -13.30 
Host: Alessandra Fiorio Pla
Guests: Manuel Garcia Aznar, head of the "Multiscale in mechanical and biological engeneering" group, University of Zaragoza; Alejandra Gozales Loyola, Senior Scientist-Maria Zambrano Fellow in the same lab.

CHROMATIN 3D ARCHITECTURE AND ITS UNDERLYING MOLECULAR MECHANISMS
Online Seminar → Link to WebEx
7th June 2023, h 14.30-15.30
Host: Sarah Perrone, III year Student CSQB 
Guest: Mario Nicodemi, Dipartimento di Fisica, Università di Napoli Federico II and INFN Napoli, Complesso Universitario di Monte Sant'Angelo, Naples, Italy
Abstract: Chromosome 3D architecture is involved in key functional processes, such as the regulation of contacts between genes and enhancers. I review recent developments in the field. Next, to understand the mechanisms underlying chromosome folding at the single-molecule level, I discuss models of polymer physics to investigate DNA loci in human HCT116 and IMR90 wild-type and Cohesin depleted cells. Our models were validated against single-cell imaging data providing evidence that mechanisms of loop-extrusion and polymer phase separation (whereby chromatin self-assembles in segregated globules) can co-exist in shaping chromatin spatial organisation. The thermodynamic degeneracy of single-molecule conformations results in broad variability of single cell DNA structures. Globules, in particular, turn out to establish stable environments where specific loop contacts are highly favoured over stochastic encounters. Cohesin depletion turns off phase separation and loop-extrusion, erasing average interaction patterns. Finally, in a reverse approach, the validated polymer structures are employed to benchmark chromatin contact technologies such as Hi-C, GAM and SPRITE.

CAR-T CELLS IN CANCER: EMERGING CONCEPTS
Online Seminar → Link to WebEx
June 8th, 2023, h 16.30-17.30
Host: Gaia Montacchiesi, III year student CSQB
Guest: Gianpiero Dotti, University of North Carolina at Chapel Hill

TRANSPOSABLE ELEMENTS
3rd July 2023

TRANSCRIPTOMICS IMAGE ANALYSIS
4th July 2023

Suggested readings and bibliography



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Teaching Modules

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Last update: 15/06/2023 16:22
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