Post-doctoral position in cell and molecular biology “Phosphoinositide 3-Kinase δ as a Target for the Diagnosis and Therapy of HCV-Induced Hepatocellular Carcinoma”

• Overview: This two-year post-doctoral position and the project entitled “Phosphoinositide 3-Kinase δ as a Target for the Diagnosis and Therapy of HCV-Induced Hepatocellular Carcinoma” are funded by ANRS France Recherche Nord & Sud Sida-hiv Hépatitis. We have demonstrated the key role of the δ isoform (PI3Kδ) of class I phosphoinositide-3 kinases in cell polarity, extracellular matrix (ECM) assembly in epithelial cells. The aim is to decipher how PI3Kd-dependent signalling pathways control plasticity and the development of HCV induced HCC resistant to treatment. The main techniques involved 3D organoid cultures from cell lines and biopsies from patients with HCV induced HCC, confocal analysis and immunohistochemistry. Epigenetic and transcriptomic and bioinformatic studies will be performed. The candidate must be familiar with advanced imaging technics and software and should have ability to drive its own research. Background in cell biology and cell signaling is required. Knowledge on HCV and bioinformatics are advantages.
• Location: Unité de Recherche INSERM-Paris-Saclay
• Duration: 2 years
• Website: here