PhD in Complex Systems for Quantitative Biomedicine

Selected research products

1. Foster JC, Arkell R, Del Giudice M, Anene C, Lauria A, Kelly J, Lemoine R, Oliviero S, Cereda M*, Rajan P*. Dysregulation of splicing-related proteins in prostate cancer is controlled by FOXA1. bioRxiv. 2018.
2. Mourikis T, Benedetti L, Foxall E, J Perner J, Cereda M, Lagergren J, Howell M, Yau C, Fitzgerald R, Scaffidi P, Ciccarelli FD. Patient-specific detection of cancer genes reveals recurrently perturbed processes in esophageal adenocarcinoma. bioRxiv. 2018.
3. Cereda M, Gambardella G, Benedetti L, Iannelli F, Patel D, Basso G, Guerra RF, Mourikis TP, Puccio I, Sinha S, Laghi L, Spencer J, Rodriguez-Justo M, Ciccarelli FD. Patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes. Nat Commun. 2016
4. Cereda M, Mourikis TP, Ciccarelli FD. Genetic Redundancy, Functional Compensation, and Cancer Vulnerability. Trends in Cancer. 2016
5. Cereda M, Pozzoli U, Rot G, Juvan P, Schweitzer A, Clark T, Ule J. RNAmotifs: prediction of multivalent RNA motifs that control alternative splicing. Genome Biol. 2014

Research topics

Our group studies cancer genomics using large-scale sequencing data to identify and characterize the molecular mechanisms driving cancer onset and progression. Through the use of mathematical and statistical models our research aims to disentangle the complexity of genomic data to provide a personalized medicine able to be incorporated into clinical practice. The group's activity focuses on identifying somatic alterations, recontructing the clonal evolution of tumors, and identifying novel molecular mechanisms that are favourable clinical intervention points. Particular interest is devoted to the study of splicing factors and their role in the onset and progression of cancer.

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